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Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition

Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition

Several studies have demonstrated that hematopoietic cells originate from endothelium in early development; however, the phenotypic progression of progenitor cells during human embryonic hemogenesis is not well described. Here, we define the developmental hierarchy among intermediate populations of hematopoietic progenitor cells (HPCs) derived from human embryonic stem cells (hESCs).

Genetic variation in metabolic phenotypes: study designs and applications

Genetic variation in metabolic phenotypes: study designs and applications

Many complex disorders are linked to metabolic phenotypes. Revealing genetic influences on metabolic phenotypes is key to a systems-wide understanding of their interactions with environmental and lifestyle factors in their aetiology, and we can now explore the genetics of large panels of metabolic traits by coupling genome-wide association studies and metabolomics.
Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGF beta Suppression

Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGF beta Suppression

ETS transcription factors ETV2, FLI1, and ERG1 specify pluripotent stem cells into induced vascular endothelial cells (iVECs). However, iVECs are unstable and drift toward nonvascular cells. We show that human midgestation c-Kit lineage-committed amniotic cells (ACs) can be reprogrammed into vascular endothelial cells (rAC-VECs) without transitioning through a pluripotent state.

iTRAQ-Based Quantitative Protein Expression Profiling and MRM Verification of Markers in Type 2 Diabetes

iTRAQ-Based Quantitative Protein Expression Profiling and MRM Verification of Markers in Type 2 Diabetes

The pathogenesis of Type 2 diabetes mellitus (T2DM) is complex owing to molecular heterogeneity in the afflicted population. Current diagnostic methods rely on blood glucose measurements, which are noninformative with respect to progression of the disease to other associated pathologies. Thus, predicting the risk and development of T2DM-related complications, such as cardiovascular disease, remains a major challenge.
Speed Sensorless Induction Motor Drive With Predictive Current Controller

Speed Sensorless Induction Motor Drive With Predictive Current Controller

Today, speed sensorless modes of operation are becoming standard solutions in the area of electric drives. This paper presents a speed sensorless control system of an induction motor with a predictive current controller.
Quantum resources for hybrid communication via qubit-oscillator states

Quantum resources for hybrid communication via qubit-oscillator states

We investigate a family of qubit-oscillator states as resources for hybrid quantum communication. They result from a mechanism of qubit-controlled displacement on the oscillator. For large displacements, we obtain analytical formulas for entanglement and other nonclassical correlations, such as entropic and geometric discord, in those states.
Intervention in biological phenomena modeled by S-systems

Intervention in biological phenomena modeled by S-systems

Recent years have witnessed extensive research activity in modeling biological phenomena as well as in developing intervention strategies for such phenomena. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of biological phenomena. In this paper, two different intervention strategies, namely direct and indirect, are proposed for the S-system model.
Enhanced compressive response of hybrid Mg-CNT nano-composites

Enhanced compressive response of hybrid Mg-CNT nano-composites

Uniaxial compressive properties of hybrid Mg/Al–CNT nano-composites are studied in the present paper. Hybrid nano-composites were fabricated using powder metallurgy route followed by microwave assisted rapid sintering technique and hot extrusion.
Joint rate, power, and decoding order optimization of multiuser MIMO systems

Joint rate, power, and decoding order optimization of multiuser MIMO systems

We consider multiuser MIMO systems with some of the users having target-rate requirements while the other users are working on best-effort data transmission. Both multiple-access channels (MAC) and broadcast channels (BC) are considered.
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Success Stories
DeSIGN: Guided Practice for Sign Language

DeSIGN: Guided Practice for Sign Language

Children learn and practice their vocabulary through interaction with parents and friends as well as through formal instruction at school. However, for deaf children, sign language is the main...
Calcium channels determine how life begins, and ends
Calcium channels determine how life begins, and ends

Calcium channels determine how life begins, and ends

Ongoing work at Weill Cornell Medical College in Qatar (WCMC-Q) is investigating how intracellular calcium (Ca2+) signaling pathways are involved in the very beginning of life as they prepare the...
Taking gas-to-liquid technology to the next level
Taking gas-to-liquid technology to the next level

Taking gas-to-liquid technology to the next level

In the 1920s, two German scientists—Franz Fischer and Hans Tropsch—developed revolutionary chemical reactions that could transform gas into liquid. These reactions proved particularly...
Researchers build the case for wind and wave studies in Qatar
Researchers build the case for wind and wave studies in Qatar

Researchers build the case for wind and wave studies in Qatar

For the first time, fine detail about the wind and wave conditions around the coast of Qatar has been recorded. By arranging the most sophisticated equipment available on the edge of a 500-meter...
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