Publications

Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition

Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition

Several studies have demonstrated that hematopoietic cells originate from endothelium in early development; however, the phenotypic progression of progenitor cells during human embryonic hemogenesis is not well described. Here, we define the developmental hierarchy among intermediate populations of hematopoietic progenitor cells (HPCs) derived from human embryonic stem cells (hESCs).

Genetic variation in metabolic phenotypes: study designs and applications

Genetic variation in metabolic phenotypes: study designs and applications

Many complex disorders are linked to metabolic phenotypes. Revealing genetic influences on metabolic phenotypes is key to a systems-wide understanding of their interactions with environmental and lifestyle factors in their aetiology, and we can now explore the genetics of large panels of metabolic traits by coupling genome-wide association studies and metabolomics.

Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGF beta Suppression

Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGF beta Suppression

ETS transcription factors ETV2, FLI1, and ERG1 specify pluripotent stem cells into induced vascular endothelial cells (iVECs). However, iVECs are unstable and drift toward nonvascular cells. We show that human midgestation c-Kit lineage-committed amniotic cells (ACs) can be reprogrammed into vascular endothelial cells (rAC-VECs) without transitioning through a pluripotent state.

RSS

Theme picker

DeSIGN: Guided Practice for Sign Language

DeSIGN: Guided Practice for Sign Language

Children learn and practice their vocabulary through interaction with parents and friends as well as through formal instruction at school. However, for deaf children, sign language is the main...
Calcium channels determine how life begins, and ends
Calcium channels determine how life begins, and ends

Calcium channels determine how life begins, and ends

Ongoing work at Weill Cornell Medical College in Qatar (WCMC-Q) is investigating how intracellular calcium (Ca2+) signaling pathways are involved in the very beginning of life as they prepare the...
Taking gas-to-liquid technology to the next level
Taking gas-to-liquid technology to the next level

Taking gas-to-liquid technology to the next level

In the 1920s, two German scientists—Franz Fischer and Hans Tropsch—developed revolutionary chemical reactions that could transform gas into liquid. These reactions proved particularly...
Researchers build the case for wind and wave studies in Qatar
Researchers build the case for wind and wave studies in Qatar

Researchers build the case for wind and wave studies in Qatar

For the first time, fine detail about the wind and wave conditions around the coast of Qatar has been recorded. By arranging the most sophisticated equipment available on the edge of a 500-meter...
RSS

Theme picker