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Haya H Al Muhannadi
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Population Genetic Structure of the People of Qatar

Author(s): Hunter-Zinck, H (Hunter-Zinck, Haley); Musharoff, S (Musharoff, Shaila); Salit, J (Salit, Jacqueline); Al-Ali, KA (Al-Ali, Khalid A.); Chouchane, L (Chouchane, Lotfi); Gohar, A (Gohar, Abeer); Matthews, R (Matthews, Rebecca); Butler, MW (Butler, Marcus W.); Fuller, J (Fuller, Jennifer); Hackett, NR (Hackett, Neil R.); Crystal, RG (Crystal, Ronald G.); Clarks, AG (Clarks, Andrew G.)

People of the Qatar peninsula represent a relatively recent founding by a small number of families from three tribes of the Arabian Peninsula, Persia, and Oman, with indications of African admixture. To assess the roles of both this founding effect and the customary first-cousin marriages among the ancestral Islamic populations in Qatar's population genetic structure, we obtained and genotyped with Affymetrix 500k SNP arrays DNA samples from 168 self-reported Qatari nationals sampled from Doha, Qatar. Principal components analysis was performed along with samples from the Human Genetic Diversity Project data set, revealing three clear clusters of genotypes whose proximity to other human population samples is consistent with Arabian origin, a more eastern or Persian origin, and individuals with African admixture. The extent of linkage disequilibrium (LD) is greater than that of African populations, and runs of homozygosity in some individuals reflect substantial consanguinity. However, the variance in runs of homozygosity is exceptionally high, and the degree of identity-by-descent sharing generally appears to be lower than expected for a population in which nearly half of marriages are between first cousins. Despite the fact that the SNPs of the Affymetrix 500k chip were ascertained with a bias toward SNPs common in Europeans, the data strongly support the notion that the Qatari population could provide a valuable resource for the mapping of genes associated with complex disorders and that tests of pairwise interactions are particularly empowered by populations with elevated LD like the Qatari.

Author(s):  Hunter-Zinck, H (Hunter-Zinck, Haley); Musharoff, S (Musharoff, Shaila); Salit, J (Salit, Jacqueline); Al-Ali, KA (Al-Ali, Khalid A.); Chouchane, L (Chouchane, Lotfi); Gohar, A (Gohar, Abeer); Matthews, R (Matthews, Rebecca); Butler, MW (Butler, Marcus W.); Fuller, J (Fuller, Jennifer); Hackett, NR (Hackett, Neil R.); Crystal, RG (Crystal, Ronald G.); Clarks, AG (Clarks, Andrew G.)
Addresses:  : [Clarks, Andrew G.] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14850 USA; [Hunter-Zinck, Haley; Musharoff, Shaila] Cornell Univ, Program Computat Biol & Med, Ithaca, NY 14850 USA; [Salit, Jacqueline; Butler, Marcus W.; Fuller, Jennifer; Hackett, Neil R.; Crystal, Ronald G.] Weill Cornell Med Coll, Dept Med Genet, New York, NY 10021 USA; [Al-Ali, Khalid A.] Qatar Univ, Dept Hlth Sci, Coll Arts & Sci, Doha, Qatar; [Chouchane, Lotfi; Gohar, Abeer; Matthews, Rebecca] Weill Cornell Med Coll Qatar, Dept Med Genet, Doha, Qatar
Source:  AMERICAN JOURNAL OF HUMAN GENETICS, 87 (1): 17-25 JUL 9 2010
DOI: 10.1016/j.ajhg.2010.05.018
Publisher:  CELL PRESS
Funding Agency:  We thank the volunteers from Qatar who donated DNA. These studies were supported in part by the Qatar Foundation and Weill Cornell Medical College in Qatar. H.H.-Z. and S.M. were supported by the Tr-Institutional Training Program in Computational Biology and Medicine at Cornell University. This work was supported in part by National Institutes of Health research grants HG003229, MH084685, and HL084706.
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